The North American Nitrogen Centre of INI (Including: US Environmental Protection Agency, US Department of Agriculture, US Geological Survey, Agriculture and Agri-Food Canada, University of Virginia,) (NANC) fosters collaboration of governmental and non-governmental organizations, universities and private individuals who are collectively trying to develop successful voluntary or regulatory ways of reducing Nr losses from agriculture and the built environment. Environmental endpoints, or critical loads, for terrestrial and aquatic ecosystems are actively researched. Workshops and synthesis activities drawing together continental-wide evaluations of both the state of knowledge and the socio-economic impediments to increasing crop NUE are supported and results are presented to stakeholders and peers at professional society venues.